Saccharomyces cerevisiae show low levels of traversal across human endothelial barrier in vitro

is generally considered safe, and is Background Saccharomyces cerevisiae involved in the production of many types of foods and dietary supplements. However, some isolates, which are genetically related to strains used in brewing and baking, have shown virulent traits, being able to produce infections in humans, mainly in immunodeficient patients. This can lead to systemic infections in humans. : In this work, we studied isolates in an in vitro human Methods S. cerevisiae endothelial barrier model, comparing their behaviour with that of several strains of the related pathogens and . Candida glabrata Candida albicans : The results showed that this food related yeast is able to cross the Results endothelial barrier . However, in contrast to and , in vitro C. glabrata C. albicans showed very low levels of traversal. S. cerevisiae : We conclude that using an human endothelial barrier Conclusions in vitro model with can be useful to evaluate the safety of S. cerevisiae S. cerevisiae strains isolated from foods. Referee Status: